The composition of total fatty acids of
Streptomyces hygroscopicus
, strain 111-81 and of its
spontaneous mutants was analysed by capillary gas chromatography.
Parent culture and most variants, white and oligosporic showed
similar fatty acid profiles and antibiotic metabolites. Asporogenic
and Nocardia-like variants were characterised by different
antibiotic spectra and by shifts in fatty acid ratios compared with
the parent strain. Results are discussed with reference to
antibiotic biosynthesis.
