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Actinomycetes
University of Udine, Mycology Department
ISSN: 0732-0574
Vol. 3, No. 2, 1992
Bioline Code: ac92006
Full paper language: English
Document type: Research Article
Document available free of charge

Actinomycetes, Vol. 3, No. 2, 1992

 en Cloning of sinefungin biosynthetic genes from Streptomyces incarnatus to Streptomyces lividans

Abstract

Actinomycetes, 1992 Vol.3 Part 2 25-30

CLONING OF SINEFUNGIN BIOSYNTHETIC GENES FROM STREPTOMYCES
INCARNATUS TO STREPTOMYCES LIVIDANS

HALINA MALINA(1), FRANCOISE LAWRENCE, and MALKA ROBERT-GERO

Code Number: AC95006
Sizes of Files:
    Text: 20K
    Graphics: Line Drawings (gif) 31K
              Photos (jpg) 21K / Halftones (gif) 33K

    ABSTRACT. Biosynthetic genes (sin genes) of sinefungin, a
transmethylase inhibitor, antifungal and antiparasitic
nucleoside antibiotic produced by Streptomyces incarnatus,
were shotgun cloned into Streptomyces lividans. The genes are
clustered on a 14 kb fragment of DNA. The expression of the
sin gene cluster in S. lividans leads to the production of a
sinefungin-like antibiotic. The compound has antifungal and
antiparasitic activities in vitro. The expression of the gene
cluster in S.lividans and E. coli causes an astringent-like
response.


Copyright 1992 CETA

 

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