search
for
 About Bioline  All Journals  Testimonials  Membership  News


Annals of African Medicine
Annals of African Medicine Society
ISSN: 1596-3519
Vol. 3, No. 1, 2004, pp. 10-12
Bioline Code: am04004
Full paper language: English
Document type: Research Article
Document available free of charge

Annals of African Medicine, Vol. 3, No. 1, 2004, pp. 10-12

 en The Prevalence of Hepatitis B Surface Antigenaemia in Patients with Human Immunodeficiency Virus (HIV) Infection in Gombe, Nigeria
Mustapha, S. K. & Jibrin, Y.B.

Abstract

Background: Both Hepatitis Virus B (HBV) and HIV infection are highly endemic in Nigeria and are important causes of morbidity and mortality. Co-infection is known to occur since the two viruses share common modes of transmission. HBV is known to produce a protein X that can stimulate the replication of HIV in vitro, and it has been observed that HIV positive men with HBV infection are at increased risk of liver related mortality.
Methods: Two hundred consecutively recruited HIV-infected individuals comprising 97 males and 103 females were screened for HBsAg using ELISA. HIV-negative blood donors in the same area were used as controls.
Results: Fifty-three of the patients tested positive for HBsAg giving an overall prevalence rate of 26.5% which was significantly higher (p < 0.001) than the 10.4% recorded among non-HIV-infected individuals. Co-infection rate in males (24.7%) did not differ significantly from that of females (28.2%). Co-infection was highest in the 40-49 years age group (41.6%), while no case of co-infection was recorded in the ≤ 19 years. Among the different occupational groups businessmen had the highest co-infection rate (44%) followed by long distance drivers (39.5%). In relation to marital status, divorcees/widows had the highest proportion of those with co-infection (53%) followed by those who were unmarried (32.5%) and those married (21.6%).
Conclusion: This study confirms the high prevalence rate of HBV co-infection in HIV-infected patients compared to the non-HIV- infected population. Therefore, there is a need to screen all HIV-infected patients for HBV infection.

Keywords
Hepatitis B surface antigen, HIV infection

 
© Copyright 2004 - Annals of African Medicine.
Alternative site location: http://www.annalsafrmed.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil