Australasian Biotechnology,
Volume 6 Number 4, July/August 1996,pp.230-237
Production of therapeutic proteins in yeasts: A review
Prasad Rallabhandi and Pak-Lam Yu,
Code Number: AU96009
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ABSTRACT
This paper reviews the use of yeasts in the production of
heterologous proteins with a special focus on therapeutic
proteins. Yeast offers a number of advantages as an expression
system over prokaryotic systems. Yeasts are eukaryotic in
nature with consequent associated cellular processes such as
protein secretion and post-translational modification of
proteins to render the recombinant proteins biologically
active. This is essential for the naturally secreted
therapeutic proteins. With the combination of recombinant
techniques and fermentation technology, it is possible to
explore yeasts as hosts for the expression and secretion of
medically important proteins.
Copyright 1996 Australian Biotechnology Association Ltd.
