Australasian Biotechnology,
Volume 7 Number 6, November/December 1997, pp.363-368
Direct conversion of cellulose to ethanol by engineered filamentous fungi
Robin A Lockington and Joan M Kelly
Code Number: AU97050
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The use of mutations and transgenes to increase the production of ethanol
by the aerobic cellulolytic fungus, Aspergillus nidulans, have been
investigated. A. nidulans was shown to produce ethanol under anaerobic
conditions, and mutations in genes required for ethanol consumption allowed
ethanol production under aerobic conditions. Other mutations were also
found to increase ethanol production, as was the introduction of extra
copies of the A. nidulans genes involved in ethanol production to produce
multicopy transgenic strains. Mutations in several genes that lead to
deregulation of glucose repression in A. nidulans were found to increase
the production of exo-cellulases.
Copyright 1997 Australian Biotechnology Association Ltd.
