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Australasian Biotechnology (backfiles)
ISSN: 1036-7128
Vol. 8, No. 2, 1998
Bioline Code: au98017
Full paper language: English
Document type: Research Article
Document available free of charge

Australasian Biotechnology (backfiles), Vol. 8, No. 2, 1998

 en Apical Membrane Antigen 1: A Leading Malaria Vaccine Candidate


Australasian Biotechnology,
Volume 8 Number 2, March/April 1998, pp. 91-95

Apical Membrane Antigen 1: A Leading Malaria Vaccine Candidate

Robin F. Anders, Pauline E. Crewther and Anthony N. Hodder,

Code Number:AU98017
Sizes of Files:
Text: 23K
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The development of a malaria vaccine remains one of the world's major public health priorities. Numerous proteins in several different life cycle stages have been identified as potential vaccine components. In the asexual blood stages of Plasmodium falciparum two antigens, merozoite surface protein 1 (MSP1) and apical membrane antigen 1 (AMA1) stand out as the leading vaccine candidates because of the extensive assessment of vaccines containing these antigens in animal models of the human disease. Studies in monkeys and mice have shown that AMA1 can induce antibody-mediated protective immune responses. Diversity in AMA1 exists but whether this limits the efficacy of an AMA1 vaccine will need to be examined in clinical trials carried out in areas where malaria is endemic.

Copyright 1998 Australian Biotechnology Association Ltd.


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