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Australasian Biotechnology (backfiles)
AusBiotech
ISSN: 1036-7128
Vol. 8, No. 2, 1998
Bioline Code: au98018
Full paper language: English
Document type: Research Article
Document available free of charge

Australasian Biotechnology (backfiles), Vol. 8, No. 2, 1998

 en Diversified Prime and Boost Protocols: The Route to Enhanced Immune Responses to Recombinant DNA Based Vaccines?

Abstract

Australasian Biotechnology,
Volume 8 Number 2, March/April 1998, pp. 96-98

Diversified Prime and Boost Protocols: The Route to Enhanced Immune Responses to Recombinant DNA Based Vaccines?

By Dr. David B. Boyle,

Code Number:AU98018
Sizes of Files:
Text: 12K
Graphics: No associated graphics files

Practically useful vaccination procedures may require both an initial priming exposure to antigen, plus an additional boosting exposure. Diversified "prime and boost protocols" provide a means of generating elevated immune responses and extending the duration of immunity for new generation vaccines based on recombinant DNA expressed antigens (as subunit antigens, vector based or naked DNA). Enhanced responses have been observed for viral, parasite and cancer vaccines. In any vaccine study an evaluation of diversified prime and boost protocols is warranted. The immunological mechanisms responsible for the elevated responses have not been defined. A detailed investigation of the mechanisms is needed.

Copyright 1998 Australian Biotechnology Association Ltd.

 

Alternative site location: http://www.ausbiotech.org/content.asp?pageid=16

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