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The IFN ganma pathophysiology: The role of soluble IFNganmaR alpha chain Bello, Yraldo; Martinto, A.; Suarez, Marisela; Penton, Giselle; Apezteguia, Isabel; Fernandez, O.; Menendez, Alfredo; Aguet, Michel & Saura, Pedro Lopez Abstract Some experimental findings point to a disease-promoting role of IFNganma in several pathological status as multiple sclerosis, systemic lupus erithematosus, type I diabetes, septic shock and others. In the case of rheumatoid arthritis (RA) specially the route of administration are of critical importance in determining the effects of IFNganma. We showed for the first time the altered levels of the IFNganmaR alpha chain in patients with AR and some RFLP of genomic DNA. The IFNganmaR alfa chain soluble fragment was cloned and expressed in E. coli.

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