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High-dose Alpha-interferon Treatment in Amyotrophic Lateral Sclerosis Farkkila, Markus; Laaksovirta, Hannu; Hokkanen, Laura & Cantell, Kari Abstract Twenty four patients with the spinal form of amyotrophic lateral sclerosis (ALS), 10 in an open series and 14 in a randomized placebo controlled manner, were treated with a short, single course of the maximum tolerated dose of natural alpha interferon. The drug was administered as a continuous intravenous infusion in the course of four to six days. The doses ranged between 250 and 950 million IU, (a mean of 560 IU). Such high-doses caused notable side-effects which were dose limiting; tiredness and fatigue up to unconsciousness were the most common. Reversible leukopenia was also observed. The mean survival time for interferon-treated patients (N = 19) was 42.6 months, and for placebo-treated patients (N = 5) 30.0 months. These results suggest that the maximum tolerated interferon dose was reached without a notable change in the course of ALS. Keywords maximum IFN dose

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Farkkila, Markus; Laaksovirta, Hannu; Hokkanen, Laura & Cantell, Kari Resumen Se trataron 24 pacientes con la forma espinal de esclerosis lateral amiotrofica (ALS), 10 en una serie abierta y 14 de forma aleatorizada, controlada, con un ciclo dnico, corto de la dosis maxima tolerable de interferon alfa natural. La droga se administro en una infusion intravenosa continua durante cuatro a seis dias. Las dosis estuvieron entre 250 y 950 millones de UI (promedio 560 millones UI). Dosis tan altas produjeron efectos secundarios notables, que fueron limitantes de la dosis. El cansancio y fatiga hasta la inconsciencia fueron los mas frecuentes, asi como leucopenia reversible. La supervivencia promedio de los pacientes que recibieron interferon (N = 19) fue de 42,6 meses y la de los que recibieron placebo (N = 5) fue de 30,0 meses. Los resultados sugieren que se alcanzo la dosis maxima tolerable de interferon sin un cambio notable en el curso de la ALS. Palabras-clave dosis maxima de IFN

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