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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 16, No. 2, 2004, pp. 122-131
Bioline Code: bk04029
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 16, No. 2, 2004, pp. 122-131

 en Evaluation Of Anti-Diarrhoeal Property Of Crude Aqueous Extract Of Ocimum Gratissimum check for this species in other resources L. (Labiatae) In Rats
Ezekwesili, C.N.; Obiora, K.A. & Ugwu, O.P.

Abstract

The anti-diarrhoeal property of aqueous extract of Ocimum gratissimum check for this species in other resources was investigated in Wistar albino rats. Aqueous leaf extract of this plant, at various doses tested (25, 50 & 100mg/kg body weight) displayed remarkable anti-diarrhoeal activity evidenced by the reduction in the rate of defecation and consistency of faeces in albino rats. The protective role of Ocimum gratissimum extract at 100mg/kg body weight was comparable to that of the reference drug, diphenoxylate (50mg/kg body weight). Ocimum gratissimum extract mimicked the action of adrenaline and noradrenaline on isolated guinea pig ileum by abolishing the acetylcholine - induced contraction of the smooth muscles of ileum and also exhibited anti-inflammatory action against agar - induced rat paw oedema in the dose range of 100 to 400mg/kg body weight. Like phenylbutazone, the ability of the extract to block oedemogenesis was more manifest at the second phase (5 - 6hrs) after induction of inflammation) of the reactions.

Keywords
Anti-diarrhoeal, Ocimum gratissimum, Oedemogenesis, Anti-inflammatory, Diphenoxylate

 
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