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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 17, No. 1, 2005, pp. 27-32
Bioline Code: bk05005
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 17, No. 1, 2005, pp. 27-32

 en Increased Liver Alkaline Phosphatase And Aminotransferase Activities Following Administration Of Ethanolic Extract Of Khaya Senegalensis check for this species in other resources Stem Bark To Rats
Yakubu, Musa T.; Adebayo, Oluwatope J.; Egwim, Evans C. & Owoyele, Victor B.

Abstract

The effect of daily, oral administration of ethanolic extract of Khaya senegalensis check for this species in other resources stem bark (2mg/kg body weight) for 18 days on the alkaline phosphatase, aspartate and alanine aminotransferase activities of rat liver and serum were investigated. Compared with the control, the activities of liver alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased significantly for the 6 and 18 days period of extract administration (P<0.05) without corresponding significant increase in the serum enzymes (P>0.05). The results indicate that the ethanolic extract of Khaya senegalensis stem bark has brought about induction of synthesis of the liver enzymes studied which is an important biochemical symptom of cytolysis.

Keywords
Khaya senegalensis, Stem bark, Ethanolic extract, Alkaline phosphatase, Aspartate aminotransferase, Alanine aminotransferase

 
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