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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 17, No. 1, 2005, pp. 51-56
Bioline Code: bk05009
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 17, No. 1, 2005, pp. 51-56

 en Non-specific Cell-mediated Immunity In Nigerian Children With Uncomplicated Malaria
Arinola, Ganiyu O.; Ugwuja, Emmanuel I.; Salimonu, Lekan S.; Adedapo, Kayode S. & Falusi, Adyinka G.

Abstract

Non-specific cellular immunity was determined in 59 Nigerian children aged between 1-9 years with uncomplicated malaria and 93 age-matched uninfected controls using percentage migration index (%M.I) and Mantoux tuberculin skin test. The mean %M.I (using malaria Pf 155 antigen) was significantly lower in malaria subjects compared with the controls (p<0.05) while the mean diameter of tuberculin skin reaction (using Purified Protein Derivative of Mycobacterium butyricum check for this species in other resources ) was significantly lower in children with uncomplicated malaria compared with the controls (p<0.05). The mean total white blood cell count (TWBC) was also significantly reduced in the malaria subjects when compared with the controls (p<0.05). The results show that leucocytes of children with uncomplicated malaria exhibited effective adaptive immune response. This may help to combat initial contact with malaria parasites.

Keywords
Migration index, uncomplicated malaria, children, immunity, Pf 155

 
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