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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 17, No. 2, 2005, pp. 83-94
Bioline Code: bk05012
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 17, No. 2, 2005, pp. 83-94

 en Uncoupling Proteins 2 And 3 Alter Mitochondrial Membrane Phospholipid Fatty Acyl Composition In Yeast
Ocloo, Augustine

Abstract

Mouse UCP1, human UCP2 and UCP3 were expressed in yeast ( Saccharomyces cerevisiae check for this species in other resources ). Total phospholipids were extracted and their fatty acyl composition was analysed. Expression of hUCP2 and hUCP3 significantly altered the mitochondrial phospholipid fatty acyl composition. Palmitoleoyl groups (16:1(n-7)) decreased while oleoyl groups (18:1(n-9)) increased, leading to a significant increase in the 18:1(n-9)/16:1(n-7) ratio and in the average chain length. Expression of mUCP1 did not cause any significant changes in fatty acyl composition

Keywords
Yeast, Saccharomyces cerevisiae, phospholipid, fatty acyl group, uncoupling protein, adenine nucleotide translocase, desaturase

 
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