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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 17, No. 2, 2005, pp. 143-147
Bioline Code: bk05020
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 17, No. 2, 2005, pp. 143-147

 en Enhancement Of Acetaminophen Overdosage-induced Hepatotoxicity By Coconut Water
Nwanjo, Harrison U.; Nwokoro, Emma A. & Ojiako, Okey A.

Abstract

Coconut water was investigated for its possible effect on the acetaminophen (paracetamol) overdosage-induced hepatotoxicity in three groups of albino Wistar rats. Administration of the minimum toxic dose of paracetamol (150mg/kg body weight) to animals (group II) produced significantly (P≤0.05) higher levels of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities when compared to the control group (group I). There was however no significant (P≤0.05) aspartate aminotransferase (AST) activity. Significantly (p<0.05) higher ALP and ALT activities were also observed in group III (the group administered with paracetamol and treated with coconut water) when compared with the control (group I) and the paracetamol-overdosed group (group II) indicating that the coconut water may have rather enhanced the toxicity of acetaminophen overdosage on the liver. The common use of coconut water as a palliative for drug overdosage is therefore contraindicated.

Keywords
Acetaminophen overdosage, hepatotoxicity, coconut water

 
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