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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 19, No. 1, 2007, pp. 9-15
Bioline Code: bk07002
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 19, No. 1, 2007, pp. 9-15

 en Synthesis, Characterization And Antibacterial Activity Of Aspirin And Paracetamol-metal Complexes
Lawal, Amudat & Obaleye, Joshua A.

Abstract

Novel complexes of Co (11), Ni (11) and Fe (111) with aspirin and paracetamol have synthesized and characterized using infrared, electronic and Hnmr spectral, melting point and conductivity measurements. The two ligands have been found to act as bidentate chelating agents. Aspirin complexes coordinate through the carbonyl oxygen of the carboxyl and the ester groups, while paracetamol complexes coordinate through the oxygen of the hydroxyl and the amide groups. Antibacterial screening of the complexes against Bacillus substilis check for this species in other resources , serratia species and Escherichia coli check for this species in other resources , was also investigated. The metal complexes were found to have varied degree of inhibitory effect against the bacteria.

Keywords
Aspirin, paracetamol, metal complexes, antibacterial activity

 
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