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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 19, No. 1, 2007, pp. 17-21
Bioline Code: bk07003
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 19, No. 1, 2007, pp. 17-21

 en Hepatoprotective Effects Of Garcinia Kola check for this species in other resources Seed Against Hepatotoxicity Induced By Carbon Tetrachloride In Rats
Wegwu, Mathew O. & Didia, Blessing C.

Abstract

The protective effects of Garcinia kola check for this species in other resources against a dose of Carbon-Tetrachloride (CC14)-induced liver damage in experimental rats were investigated. The CC14 induction (administered intraperitoneally, 0.5m1/kg body weight in olive oil-0.5ml/kg body weight) led to significant increases in the levels of serum aspartate and alanine amino transferases, alkaline phosphatase and lipid peroxides in CC14 intoxicated rats. Pretreatment with varied concentrations of Garcinia kola diets (1%, 5% and 10%) and vitamin E (9%,) for 21 days prior to CC14 administration resulted in significant decreases in Liver marker enzymes and lipid peroxides. These findings suggest that Garcinia kola seed may be acting as a natural antioxidant that prevents hepatic oxidative stress induced by CC14.

Keywords
hepatoprotective, garcinia kola, liver marker enzymes, lipid peroxides

 
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