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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 23, No. 1, 2011, pp. 21-27
Bioline Code: bk11004
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 23, No. 1, 2011, pp. 21-27

 en Antibacterial and antioxidant properties of macrocyclic Schiff bases with vanadium (V) complexes
Pawar, Vatsala; Joshi, Sunil & Uma, V.

Abstract

Macrocyclic Schiff bases have been synthesized by the condensation of acetyl acetone with semicarbazide hydrochloride and thiosemicarbazide in presence of methanol. Further, their oxovanadium complexes have been synthesized by using vanadium acetylacetone. The structural assignment of these compounds has been made on the basis of MP, TLC, MW determination, conductivities, elemental analysis and UV, IR and 1HNMR spectral datas. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., Staphylococcus aureus check for this species in other resources , Bacillus licheniformis check for this species in other resources , Escherichia coli check for this species in other resources and Micrococcus luteus check for this species in other resources (ATCC) and were compared with the standard antibiotic oflaxocin. Also in-vitro antioxidant activity of all compounds was determined by nitric acid free radical scavanging assay.

Keywords
Macrocyclic Schiff Bases; Vanadium complexes; Antibacterial; Antioxidant activities.

 
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