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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 24, No. 1, 2012, pp. 1-14
Bioline Code: bk12001
Full paper language: English
Document type: Review Article
Document available free of charge

Biokemistri, Vol. 24, No. 1, 2012, pp. 1-14

 en Pharmacology of organoselenium compounds: Emphasis on puzzling mechanistic switching from their glutathione peroxidase mimic in vivo
Kade, Ige J. & da Rocha, Joao B. Teixeira

Abstract

Organoselenium compounds are a new class of emerging potent antioxidants. Basically, their rational design and synthesis was aimed at mimicking the native glutathione peroxidase enzyme in their reduction of hydroperoxides at the expense of the ubiquitous antioxidant, glutathione. In this review, emphasis was focused on the seemingly antagonistic mechanisms employed by organoseleniums under in vitro and in vivo conditions. Summarily, in vitro evidences clearly demonstrate that the pharmacological effect of organoseleniums strictly depends on their GPx mimic. However, these selenium based compounds evoke an increase in the level of endogenous thiols suggesting a possible switch in their glutathione peroxidase mimic under in vivo conditions. Apparently, this mechanistic switch is puzzling and requires concerted efforts to unravel.

 
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