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Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 24, No. 1, 2012, pp. 52-57
Bioline Code: bk12007
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 24, No. 1, 2012, pp. 52-57

 en Consequences of long-term consumption of water from Nworie River (Owerri, Nigeria) on haematological, hepatic, and renal functions using rat model
Duru, Majesty K. C. Duru; Adindu, Eze A.; Odika, Prince C.; Amadi, Benjamin & Okazi, Chima-Ezika R.

Abstract

The consequences of long term consumption of water from Nworie River (Owerri, Nigeria) on haematological, hepatic, and renal functions using rat model (Wistar albino strain). Twenty-four rats separated into two groups of twelve rats each were kept as test and control for sixty-four days. The test rats were placed on water from Nworie River while those of the control were placed on Eva water (purified Coca-cola bottled water). The rats were sacrificed in two sets: first set was on thirty-second day while the second set was on the sixty-fourth day. Six rats each from each group were sacrificed at each set. The Results obtained revealed that Hb, PCV, WBC, L, N, and ESR were significantly affected (p<0.05) in test rats against the control rats. The functional parameters of liver adequacy; AST, ALT, and ALP were significantly (p<0.05) affected in test rats against those of the control. Also, urea and electrolyte ions (Potassium ion, chloride and bicarbonate) indicating renal sufficiency were significantly (p<0.05) affected in test rats against those of the control. Creatinine, sodium ion, total bilirubin and conjugated bilirubin were not significantly affected (p>0.05) in test rats when compared to those of the control. The induced changes in the parameters investigated in this study have shown that long-term consumption of water from Nworie River has effect on haematological, hepatic, and renal function.

Keywords
Nworie River, haematology, liver function, kidney function

 
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