search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 27, No. 1, 2015, pp. 22-25
Bioline Code: bk15004
Full paper language: English
Document type: Research Article
Document available free of charge

Biokemistri, Vol. 27, No. 1, 2015, pp. 22-25

 en Potential haematopoietic properties of crude methanolic seed extract of Pentaclethra macrophylla check for this species in other resources in Wistar rats.
Ufelle, Silas A.; Neboh, Emeka E.; Achukwu, Peter U. & Ghasi, Samuel

Abstract

Numerous medicinal properties have been attributed to the seeds of Pentaclethra macrophylla check for this species in other resources (P. macrophylla) whereas its haematological properties have received little attention. This study was designed to evaluate the haematopoietic effects of crude methanolic seed extract of P. macrophylla in wistar rats. Thirty Wistar rats in five groups, labeled A to E were acclimatized for two weeks and used for this study. Groups A to D were administered orally with graded-doses of crude methanolic extract of P. macrophylla seeds (100, 200, 300 and 400) mg/kg body weight respectively for 28 days whereas Group E served as control. Blood sample was collected and haematological parameters were determined. Extracts of P. macrophylla significantly (p<0.05) increased the Hb, Hct, RBC and TWBC in a dose-dependent pattern in the treated groups compared to the control. The platelet count was however decreased in the treated groups compared with the control, although not in a dose-dependent pattern, with Group D having the least count (p<0.05). Thin blood films of the treated groups revealed normocytic and normochromic red blood cells and relative lymphocytosis. Administration of crude methanolic seed extract of Pentaclethra macrophylla demonstrated dosage-dependent significant increase in some haematological variables, while decreasing platelet count. This study suggests that the seed extract may possess haematopoietic, antimicrobial and immunity boosting potentials, and could be developed for future clinical use in managing blood-related conditions.

Keywords
Graded-doses; Oral administration; Pentaclethra macrophylla

 
© Copyright 2015 - Biokemistri

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 16-Oct-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil