BioSafety, Volume 1, Paper 8 (BY95008), June 27th 1995
Online Journal, URL -
http://www.bdt.org.br/bioline/by
Risk assessment of animal cell culture procedures.
G. Stacey
Received July 1st 1995
Code Number: BY95008
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SUMMARY
The generation of continuous cell lines from animal and human
tissues has yielded valuable tools for biological studies.
Some of these cell lines have also proved important hosts for
expression of recombinant DNA. The fact that cell culture is
used in diverse disciplines has meant that to a large extent
it has evaded specific attention regarding risk assessment.
The primary concern relating to safety in cell culture is that
animal cells can provide a suitable medium in which
microorganisms, notably viruses, can multiply. There are a
number of levels at which the culture and manipulation of
animal cells should be considered from the point of view of
safe handling. This overview attempts to outline the type of
approach which should be adopted in risk assessment along with
some practical suggestions to promote safe handling of cell
cultures.
