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Indian Journal of Critical Care Medicine
Medknow Publications on behalf of the Indian Society of Critical Care Medicine
ISSN: 0972-5229
EISSN: 1998-359x
Vol. 12, No. 4, 2008, pp. 181-189
Bioline Code: cm08036
Full paper language: English
Document type: Special Article
Document available free of charge

Indian Journal of Critical Care Medicine, Vol. 12, No. 4, 2008, pp. 181-189

 en Biological agents targeting beyond TNF-alpha
Sharma, Rashmi; Sharma, Chaman Lal & Mahajan, Annil

Abstract

Biological agents represent an important addition to the therapies for immuno-inflammatory conditions and have a great impact on the disease course and quality of life of these patients. However, recent reports of serious infections like tuberculosis, demyelinating and neurodegenerative diseases, pancytopenia, cardiovascular diseases, etc. after anti-TNF therapy raised questions on their safety. Hence, focus is shifted towards drugs targeting cytokine checkpoints in the inflammatory cascades beyond TNF-a. Existing therapeutic targets include the biological agents acting as antagonists of various inflammatory cytokines (Anakinra, Tocilizumab, Atlizumab) and modulators of CD80 or CD86-CD28 co-stimulatory signal (Abatacept), CD2 receptors on T-cells (Alefacept), CD11a, subunit of leukocyte function-associated antigen 1 (Efalizumab), vitronectin receptor and CD20 antigen on pre-B, immature and mature B cells (Rituximab). With the introduction of these novel molecules the future for immunomodulatory intervention in rheumatology, asthma, crohn′s disease, septic shock etc. looks very promising. These novel therapeutic agents could truly give a new hope to the clinician to modify the disease and achieve tangible improvements in the lives of the patients.

Keywords
Biological agents; cytokines; CD20 antigen; rheumatology; T-cells

 
© Copyright 2008 Indian Journal of Critical Care Medicine.
Alternative site location: http://www.ijccm.org/

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