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Indian Journal of Critical Care Medicine
Medknow Publications on behalf of the Indian Society of Critical Care Medicine
ISSN: 0972-5229
EISSN: 1998-359x
Vol. 13, No. 2, 2009, pp. 49-53
Bioline Code: cm09013
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Critical Care Medicine, Vol. 13, No. 2, 2009, pp. 49-53

 en Colistin and polymyxin B: A re-emergence
Gupta, Sachin; Govil, Deepak; Kakar, Prem N; Prakash, Om; Arora, Deep; Das, Shibani; Govil, Pradeep & Malhotra, Ashima

Abstract

One of the greatest achievements of modern medicine is the development of antibiotics against life-threatening infections, but the emergence of multidrug-resistant (MDR) gram negative bacteria has drastically narrowed down the therapeutic options against them. This limitation has led clinicians to reappraise the clinical application of polymyxins, an old class of cationic, cyclic polypeptide antibiotics. Polymyxins are active against selected gram-negative bacteria, including the Acinetobacter check for this species in other resources species, Pseudomonas aeruginosa check for this species in other resources , Klebsiella check for this species in other resources species, and Enterobacter check for this species in other resources species. In this article, we summarise the chemistry, pharmacokinetics, and pharmacodynamics of polymyxins and the latest understanding of their action against MDR pathogens.

Keywords
Multidrug-resistant organisms, polymyxins

 
© Copyright 2009 Indian Journal of Critical Care Medicine.
Alternative site location: http://www.ijccm.org/

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