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Indian Journal of Critical Care Medicine
Medknow Publications on behalf of the Indian Society of Critical Care Medicine
ISSN: 0972-5229
EISSN: 1998-359x
Vol. 13, No. 3, 2009, pp. 163-166
Bioline Code: cm09036
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Critical Care Medicine, Vol. 13, No. 3, 2009, pp. 163-166

 en Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome
Juneja, Deven; Mohan, S; Veturi, Vivek V. & Gopal, Palepu B.


Results of the PROWESS trial suggested that heparin may reduce the efficacy of recombinant human activated protein C (rhAPC) and the XPRESS study also showed increased bleeding complications in patients receiving heparin with rhAPC. Although it has been shown that heparin prophylaxis may be used along with rhAPC, no study has shown the interaction between continuous heparin infusion and rhAPC. Here, we report a case of severe sepsis with pulmonary embolism who was concurrently administered heparin and rhAPC infusions, with positive results and no bleeding complications.

Activated protein C, heparin, pulmonary embolism, severe sepsis

© Copyright 2009 Indian Journal of Critical Care Medicine.
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