Indian Journal of Critical Care Medicine
Medknow Publications on behalf of the Indian Society of Critical Care Medicine
Vol. 14, No. 1, 2010, pp. 14-21
Bioline Code: cm10004
Full paper language: English
Document type: Review Article
Document available free of charge
Indian Journal of Critical Care Medicine, Vol. 14, No. 1, 2010, pp. 14-21
© Copyright 2010 Indian Journal of Critical Care Medicine.
Sepsis-induced acute kidney injury|
Acute kidney injury (AKI) is a common sequel of sepsis in the intensive care unit. It is being suggested that sepsis-induced AKI may have a distinct pathophysiology and identity. Availability of biomarkers now enable us to detect AKI as early as four hours after it′s inception and may even help us to delineate sepsis-induced AKI. Protective strategies such as preferential use of vasopressin or prevention of intra-abdominal hypertension may help, in addition to the other global management strategies of sepsis. Pharmacologic interventions have had limited success, may be due to their delayed usage. Newer developments in extracorporeal blood purification techniques may proffer effects beyond simple replacement of renal function, such as metabolic functions of the kidney or modulation of the sepsis cascade.
Sepsis, acute kidney injury, AKI, acute renal failure, extracorporeal purification of blood
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