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Indian Journal of Critical Care Medicine
Medknow Publications on behalf of the Indian Society of Critical Care Medicine
ISSN: 0972-5229
EISSN: 1998-359x
Vol. 14, No. 3, 2010, pp. 147-150
Bioline Code: cm10030
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Critical Care Medicine, Vol. 14, No. 3, 2010, pp. 147-150

 en Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome
Nasa, Prashant; Sehrawat, Deepak; kansal, Sudha & Chawla, Rajesh


Toxic shock syndrome (TSS) is a serious, potentially life-threatening condition resulting from an overwhelming immunological response to an exotoxin released by Staphylococcus aureus and group A streptococci. High index of suspicion, early diagnosis and aggressive therapeutic measures must be instituted in view of high mortality of the TSS. In recent years, new agents have been tested to reduce morbidity and mortality in patients with severe sepsis, in addition to standard supportive measures. Among them, recombinant human activated protein C (rhAPC) has been reported to significantly reduce mortality and morbidity in patients with severe sepsis and two or more acute organ failures. We describe our experience with this drug in the early reversal of septic shock from TSS.

Nonmenstrual toxic shock syndrome, recombinant human activated protein C, staphyloccocal exotoxin, staphylococcal toxic shock syndrome.

© Copyright 2010 Indian Journal of Critical Care Medicine.
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