The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy

Background: The optimal hemoglobin level and transfusion threshold in patients with septic shock treated with an early, goal oriented approach to resuscitation remains unknown.
Aims: To assess the impact of packed red blood cell (PRBC) transfusion on clinically relevant outcomes in patients with septic shock treated with early goal directed therapy (EGDT).
Settings and Design: Retrospective cohort study of 93 patients who presented with septic shock, to a single center academic intensive care unit and received EGDT.
Materials and Methods: Data were collected on patients identified via the Surviving Sepsis Campaign Chart Review database and linked to Project IMPACT database. The PRBC group and no PRBC group were compared by the Pearson chi-square and Fisher′s exact test to analyze statistical significance.
Results: The PRBC group had a mortality of 41.2% vs. 33.9% in the no PRBC transfusion group (P = NS). The PRBC group also had more mechanical ventilation days (11.2 days vs. 5.0 days, P ≤ 0.05), longer hospital length of stay (25.9 days vs. 12.5 days, P ≤ 0.05), and longer intensive care unit length of stay (11.4 days vs. 3.8 days, P ≤ 0.05).
Conclusions: In this retrospective cohort study, transfusion of PRBCs was associated with worsened clinical outcomes in patients with septic shock treated with EGDT. Further studies are needed to determine the impact of transfusion of PRBC within the context of early resuscitation of patients with septic shock, as the beneficial effects gained by an early and goal oriented approach to resuscitation may be lost by the negative effects associated with PRBC transfusion.

Keywords
Early goal directed therapy, packed red blood cell, septic shock, severe sepsis, transfusion