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Drug interaction leading to prolonged sedation in a postoperative high risk coronary bypass surgery patient Bobade, Shrikant; Kulkarni, Vinay; Dhumne, Sudhir; Barde, Saurabh; Chauhan, Jitesh & Sharma, Avinash Abstract Use of midazolam infusion in mechanically ventilated patient is an established practice in critical care. In our case, the use of erythromycin as a prokinetic agent for better tolerance of enteral feeding and paralytic ileus led to an interaction between midazolam and erythromycin, which resulted in prolonged and deeply sedated patient. In a critically ill patient, there is always a possibility of multiple drug interactions. It is important to understand them and they should be considered before starting new medication. Keywords Erythromycin, midazolam, prolonged sedation

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