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Indian Journal of Critical Care Medicine
Medknow Publications on behalf of the Indian Society of Critical Care Medicine
ISSN: 0972-5229
EISSN: 0972-5229
Vol. 15, No. 2, 2011, pp. 123-125
Bioline Code: cm11030
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Critical Care Medicine, Vol. 15, No. 2, 2011, pp. 123-125

 en Carbamzepine-induced toxic epidermal necrolysis
Chowta, Nithyananda K.; Chowta, Mukta N.; Ramapuram, John; Kumar, Pramod & Fazil, Abul

Abstract

Toxic epidermal necrolysis (TEN), also known as Lyell′s syndrome, is a widespread life-threatening mucocutaneous disease where there is extensive detachment of the skin and mucous membrane. Many factors involved in the etiology of TEN including adverse drug reactions. Here we are reporting a case of toxic epidermal necrolysis in an adult male patient after receiving carbamazepine in a 38 year old male. On the18th day of carbamazepine, patient developed blisters which first appeared on the trunk, chest and arms. The erythematous rash was covering almost all over the body with epidermal detachment of 70% body surface area. There was loss of eye lashes, congestion of conjunctiva with mucopurulent discharge and exposure keratitis. The clinical impression was TEN induced by carbamazepine. Carbamazepine was stopped immediately. He was treated with high dose intravenous betamethasone and systemic and topical antibiotics. After one month, the progression of the skin lesions halted and he was discharged.

Keywords
Carbamazepine, Stevens-Johnson syndrome, toxic epidermal necrolysis

 
© Copyright 2011 Indian Journal of Critical Care Medicine.
Alternative site location: http://www.ijccm.org/

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