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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 39, No. 4, 2002, pp. 139-142
Bioline Code: cn02011
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Cancer, Vol. 39, No. 4, 2002, pp. 139-142

 en Usefulness of Cytogenetics in Leukemias
Frenny J. VinSheth, Jayesh J. Sheth, Ashwin I. Patel, Ami D. Shah, Alian Verhest

Abstract

Present study consists of cytogenetic evaluation in 141 cases referred to our centre for various leukemias. This includes 110 cases of CML, 10 of ALL, 16 of AML (M3), 2 of AML(M2), 2 of MDS & 1 of CMML. The conventional cytogenetic study was carried out in all the cases using G Banding technique. Of the 141 patients studied, 17 patients showed secondary chromosomal alterations along with primary chromosomal alterations. In two patients of CML with secondary chromosomal alteration t(4:9:22), molecular cytogenetic technique (FISH) has been carried out which has confirmed the primary observations revealed by the conventional cytogenetic technique. Other secondary alterations were numerous and would have been missed if only FISH or PCR technique would have been used for diagnosis. We observed from our study that advanced molecular techniques like FISH & PCR cannot replace the conventional cytogenetic study but are useful as supportive and confirmative diagnostic tools.

Keywords
Leukemia, Cytogenetic, FISH

 
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