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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 40, No. 4, 2003, pp. 140-143
Bioline Code: cn03024
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Cancer, Vol. 40, No. 4, 2003, pp. 140-143

 en Case Report - Early Relapse after Non Myeloablative Allogeneic Stem Cell Transplantation in a Patient with Acute Promyelocytic Leukemia in Complete Molecular Remission
Tavernier E, Thomas X

Abstract

We described a 41-year-old patient with acute promyelocytic leukemia (APL) who experienced two successive relapses: one after all-trans retinoic acid (ATRA) treatment and chemotherapy, and another after ATRA treatment and chemotherapy, followed by autologous peripheral blood stem cell transplantation. A third complete remission (CR) was achieved with arsenic trioxide (As2O3) therapy. Mini-transplantation was performed as consolidation therapy. While the patient was in molecular remission at the beginning of conditioning regimen, a new relapse arose after transplantation at time of cell recovery. This raises a potential relationship between relapse and the severe immunosuppression induced by mini-transplantation. To our knowledge, this is the first description of a mini-allograft in an APL patient achieving molecular remission after As2O3 therapy.

Keywords
Acute promyelocytic leukemia, Mini-transplantation, Relapse

 
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Alternative site location: http://www.indianjcancer.com/

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