Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
Vol. 45, No. 1, 2008, pp. 30-32
Bioline Code: cn08007
Full paper language: English
Document type: Case Report
Document available free of charge
Indian Journal of Cancer, Vol. 45, No. 1, 2008, pp. 30-32
© Copyright 2008 Indian Journal of Cancer.
Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22|
Vundinti, B.R.; Kerketta, L.; Madkaikar, M.; Jijina, F. & Ghosh, K.
The t(8;21)(q22;q22) is one of the most frequent chromosomal abnormality associated with acute myeloid leukemia (AML) M2 sub type. The additional chromosomal abnormalities including structural and numerical are frequently reported with the translocation, t (8;21)(q22;q22). We report a case of AML-M2 with t(X;8;21)(p22;q22;q22) associated with loss of Y chromosome. Using a dual color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrated an ETO/AML1 fusion signal on the derivative chromosome 8 and one ETO signal on derivative Chromosome Xp22. The patient did not respond to therapy and follow-up of cytogenetics revealed same chromosome abnormality. Hence, this three way translocation involving X chromosome might be associated with poor prognosis.
Acute myeloid leukemia, AML-M2, ETO/AML fusion, Xp22
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