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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 45, No. 2, 2008, pp. 67-71
Bioline Code: cn08018
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Cancer, Vol. 45, No. 2, 2008, pp. 67-71

 en A t(X; 18) SYT-SSX2 positive synovial sarcoma in the pelvis of a young adult male: A rare case report with review of literature
Rekhi, B; Jambhekar, NA; Desai, SB; Basak, R; Puri, A & Agrawal, M

Abstract

Synovial sarcoma is uncommonly documented in the pelvis. Rarely, such cases have dealt with molecular analysis. A 19-year-old boy presented with pain and swelling in his left lower limb of two months duration. He developed acute urinary retention four days prior to his hospital admission, wherein radiological examination unraveled a large soft tissue mass, displacing his pelvic muscles, along with a lytic lesion involving his right pubic bone. Biopsy showed a cellular spindle cell sarcoma, exhibiting hemangiopericytoma-like vascular pattern with focal necrosis. Immunohistochemistry (IHC) showed positivity for vimentin, BCL-2, calponin and MIC 2. Cytokeratin (CK) and epithelial membrane antigen (EMA) were negative. MIB 1 count was 70% (high). P53 was positive. Diagnosis of a poorly differentiated synovial sarcoma was offered and confirmed with a positive t(X; 18) SYT-SSX2 translocation. This case highlights the value of molecular analysis in diagnosis of a synovial sarcoma at rare sites, especially when IHC results are equivocal and the biopsy material is limited.

Keywords
Molecular analysis, pelvic synovial sarcoma, pelvic tumors, soft tissue sarcomas, t(X; 18) SYT-SSX2 translocation.

 
© Copyright 2008 Indian Journal of Cancer.
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