Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
Vol. 45, No. 3, 2008, pp. 126-127
Bioline Code: cn08037
Full paper language: English
Document type: Research Article
Document available free of charge
Indian Journal of Cancer, Vol. 45, No. 3, 2008, pp. 126-127
© Copyright 2008 Indian Journal of Cancer.
Heterotopic bone formation in renal cell carcinoma: A diagnostic challenge|
Singh, V; Sinha, RJ; Sankhwar, SN & Dalela, D
Formation of bone in cases of renal cell carcinoma is a rare finding and only a couple of case reports from Japan and one from India are mentioned in the literature. Calcification inside renal mass has been reported earlier but the prognostic implications have not been clearly elucidated. We report a case which showed heterotopic bone formation (ossification) inside the renal mass and was managed by radical nephrectomy. The histopathology showed clear cell renal carcinoma with multiple centers of ossification in the region of calcification suggesting bone formation. In this case report we discuss bone morphogenetic proteins which have been implicated as a prognostic and causative factor, highlight the difficulties in distinguishing between calcification and bone formation on the basis of radiological investigations and mention the geographic implications of this rare phenomenon which has not been described earlier.
Bone morphogenetic proteins, carcinoma, environmental, ossification, renal cell
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