Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
Vol. 47, No. 2, 2010, pp. 139-141
Bioline Code: cn10036
Full paper language: English
Document type: Research Article
Document available free of charge
Indian Journal of Cancer, Vol. 47, No. 2, 2010, pp. 139-141
© Copyright 2010 Indian Journal of Cancer.
Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer|
Background : Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention.
Materials and Methods : In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool.
Results : According to this study, 10 strong possible ligands were identified.
Conclusion : These sites can be useful for further drug development studies.
BRCA1, ligand binding
Alternative site location: http://www.indianjcancer.com/