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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 47, No. 3, 2010, pp. 260-266
Bioline Code: cn10066
Full paper language: English
Document type: Symposium
Document available free of charge

Indian Journal of Cancer, Vol. 47, No. 3, 2010, pp. 260-266

 en Challenges in integrating 18FDG PET-CT into radiotherapy planning of head and neck cancer
Dandekar, P.; Partridge, M.; Kazi, R.; Nutting, C.; Harrington, K. & Newbold, K.


Radiotherapy forms one of the major treatment modalities for head and neck cancers (HNC), and precision radiotherapy techniques, such as intensity-modulated radiotherapy require accurate target delineation to ensure success of the treatment. Conventionally used imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging are used to delineate the tumor. Imaging, such as positron emission tomography (PET)-CT, which combines the functional and anatomic modalities, is increasingly being used in the management of HNC. Currently, 18-fluorodeoxyglucose is the most commonly used radioisotope, which is accumulated in areas of high glucose uptake, such as the tumor tissue. Because most disease recurrences are within the high-dose radiotherapy volume, defining a biological target volume for radiotherapy boost is an attractive approach to improve the results. There are many challenges in employing the PET-CT for radiotherapy planning, such as patient positioning, target edge definition, and use of new PET tracers, which represent various functional properties, such as hypoxia, protein synthesis, and proliferation. The role of PET-CT for radiotherapy planning is ever expanding and more clinical data underlining the advantages and challenges in this approach are emerging. In this article, we review the current clinical evidence for the application of functional imaging to radiotherapy planning and discuss some of the current challenges and possible solutions that have been suggested to date.

PET-CT, functional imaging, biologically targeted radiotherapy, radiotherapy, adaptive radiotherapy

© Copyright 2010 Indian Journal of Cancer.
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