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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 47, No. 3, 2010, pp. 332-338
Bioline Code: cn10079
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Cancer, Vol. 47, No. 3, 2010, pp. 332-338

 en From two-dimensional to three-dimensional conformal radiotherapy in prostate cancer: An Indian experience
Engineer, R.; Bhutani, R.; Mahantshetty, U.; Murthy, V. & Shrivastava, S. K.

Abstract

Background: Sparse data from India are available regarding the outcome of prostate cancer treatment. We report our experience in treating prostate cancer with radiotherapy (RT).
Materials and Methods: This study included 159 men with locally advanced cancer treated with RT with or without hormone therapy between 1984 and 2004. The median RT dose was 70 Gy over 35 fractions. Eighty-five patients received whole pelvic RT and prostate boost, and 74 patients were treated with 3-dimensional conformal radiotherapy (3DCRT) to prostate and seminal vesicles alone.
Results: The median follow-up was 25 months and the freedom from biochemical failure for all the patients at 5 years was 76%, disease-free survival (DFS) 59.1%, and overall survival (OAS) was 70.1%. The risk stratification (91% vs 52%, P < 0.03) and RT dose (72.8% for dose > 66 Gy vs 43.5% for dose < 66 Gy; P = 0.01) affected the DFS. DFS at 5 years was better in the group receiving 3DCRT to prostate and seminal vesicles (78% vs 51.5%; P = 0.001) and was reflected in OAS as well (P = 0.01).
Conclusion: CRT technique with dose escalation results in significant benefit in DFS and OAS in locally advanced prostate cancer.

Keywords
Three dimensional conformal radiotherapy, India, prostate cancer

 
© Copyright 2010 Indian Journal of Cancer.
Alternative site location: http://www.indianjcancer.com/

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