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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 48, No. 3, 2011, pp. 316-322

Bioline Code: cn11085
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Cancer, Vol. 48, No. 3, 2011, pp. 316-322

 en Acute promyelocytic leukemia: An experience from a tertiary care centre in north India
Bajpai, J; Sharma, A; Kumar, L; Dabkara, D; Raina, V; Kochupillai, V & Kumar, R

Abstract

Background: There are very limited data reported about acute promyelocytic leukemia (APL) from developing countries. We reviewed the clinical course and treatment outcome of APL patients treated at our center.
Materials and Methods: Between January 1997 and December 2007, 33 patients with APL received induction therapy using ATRA + daunorubicin (n = 26), As = 26), As2O3 (n = 4) or daunorubicin + cytosar ( n = 3).
Results: Median age was 30 years with a male to female ratio of 1.68. Twenty seven patients (82%) achieved CR. Complications during induction therapy were febrile neutropenia (33%), ATRA syndrome (30%), bleeding (58%), and diarrhea in (6%) patients. During induction and follow up, 8 (24.24%) patients died, 6 (18.18%) during induction, 1 (3%) during maintenance, and 1 (3%) after relapse. Median OS is 128 months while median EFS is 61 months. Four patients relapsed at a median time of 61 months. At the time of censoring, 25 patients were alive at a median follow up of 13 months (range 0.6 -127 months); 21 in CR1, 3 in CR2, 1 in CR3. Comparisons among the risk groups (CR and relapse rate and survival statistics) were not statistically significant.
Conclusions: APL is a highly curable malignancy. Our results confirm the findings of the published literature from larger cooperative studies from the West. We may further improve outcome with quicker diagnosis and more efficient supportive care system.

Keywords
Acute promyelocytic leukemia, all-trans-retinoic acid, arsenic trioxide

 
© Copyright 2011 Indian Journal of Cancer.
Alternative site location: http://www.indianjcancer.com/

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