search
for
 About Bioline  All Journals  Testimonials  Support Bioline  News


Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 48, No. 3, 2011, pp. 351-360

Bioline Code: cn11091
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Cancer, Vol. 48, No. 3, 2011, pp. 351-360

 en The Smad family and its role in pancreatic cancer
Singh, P; Wig, J D. & Srinivasan, R

Abstract

One of the major signaling pathways that determine the tumor aggression and patient outcome in pancreatic cancer is the transforming growth factor-beta (TGF-ß) pathway. It is inactivated at various levels in pancreatic cancer and plays a dual role in tumor initiation and progression. The Smad family of proteins transduce signals from the TGF-ß superfamily ligands that regulate cell proliferation, differentiation and death through activation of receptor serine/threonine kinases. This review discusses the structure, function and regulation of various participating Smad family members, and their individual roles in determining the progression and outcome of pancreatic cancer patients, with a special emphasis on Smad4.

Keywords
Pancreatic cancer, smad family, Smad4, Smad6, Smad7, transforming growth factor-beta

 
© Copyright 2011 Indian Journal of Cancer.
Alternative site location: http://www.indianjcancer.com/

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2014, Site last up-dated on 14-Apr-2014.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil