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Brain tumor and role of β-carotene, α- tocopherol, superoxide dismutase and glutathione peroxidase
Aggarwal Sarita, Subberwal Manju, kumar Sushil, Sharma Meenakshi
Abstract
The erythrocyte levels of the antioxidant enzymes SOD and GPx, and serum levels of antioxidants vitamins β -carotene and β -tocopherol were estimated in various types of brain tumors, and were compared with the levels in controls. Statistically significant (P< .001) diminished levels of β - carotene, β -tocopherol, SOD and GPx, were observed in all the brain tumor patients as compared to controls. Malignant tumor also showed a relative decrease in antioxidant levels as compared to benign tumors. Comparison of histopathological sections of brain tumors also suggested a inverse relationship between antioxidant level and grades of malignancy. Marked decrease in antioxidant levels may have a role in genesis of considerable oxidative stress in brain tumors. Further more, the degree of decline in antioxidant levels may indicate severity of malignancy in brain tumors.
Keywords
Superoxidase-dismutase, Glutathione peroxidase, β-carotene, a-tocopherol, Brain tumor
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