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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482
EISSN: 0973-1482
Vol. 2, No. 4, 2006, pp. 171-181
Bioline Code: cr06043
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Cancer Research and Therapeutics, Vol. 2, No. 4, 2006, pp. 171-181

 en Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction
Szasz A, Vincze Gy.

Abstract

We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43°C could be based theoretically as well.

Keywords
Cell-destruction, dose of hyperthermia, oncothermia, Pennes-equation

 
© Copyright 2006 Journal of Cancer Research and Therapeutics.
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