Lymphoma of frontotemporal region with massive bone destruction and intracranial and intraorbital extension

Primary non-Hodgkin′s lymphoma with unilateral proptosis and diffuse involvement of the cra¬nial vault and brain parenchyma is extremely rare. A 50-year-old woman developed a progressively increasing proptosis of her right eye, associated with a subcutaneous mass over the right frontotemporal region over the last 5 months. CT scan showed a high-density contrast-enhancing lesion with wide involvement of the cranium and intracranial and intraorbital extension. We performed a wedge biopsy for further analysis. Histological examination revealed that the tumor was non-Hodgkin′s lymphoma. There was no evidence of systemic involvement. The patient received radiotherapy and was doing well at 18 months′ follow-up. Primary malignant lymphoma involving the orbit and cranial vault is a rare malignancy, and treatment remains to be defined.