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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482
EISSN: 0973-1482
Vol. 6, No. 2, 2010, pp. 159-166
Bioline Code: cr10037
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Cancer Research and Therapeutics, Vol. 6, No. 2, 2010, pp. 159-166

 en Concurrent chemoradiation in locally advanced carcinoma cervix patients
Negi, R. R.; Gupta, Manish; Kumar, Muninder; Gupta, M. K.; Seam, R. & Rastogi, Madhup

Abstract

Purpose : To investigate the feasibility of concurrent chemo radiation in locally advanced carcinoma cervix patients in our clinical setting.

Materials and Methods : From Sept. 1 st 2005 to Aug. 31 st 2006, 102 patients of carcinoma cervix belonging to stage IIA to IV A were enrolled in the study. External beam radiation therapy was administered using Cobalt 60 teletherapy machine. Cisplatinum (40 mg/m 2 ) and 5 Fluorouracil (500 mg /m 2 ) continuous infusions with radiotherapy on D2-D5 in first and last 5 # of radiation therapy were administered.

Results : Response to treatment and toxicities were monitored and analyzed in 102 patients (50 study group and 52 control group). All 102 patients completed treatment. Out of 50 patients in the study group, 30, 10 and 4 patients had complete, partial and progressive disease, respectively. While out of 52 patients in the control group, 26 had complete and 12 showed partial response. No difference in overall renal, hematological and cutaneous toxicity was seen between two groups.

Conclusion : This study did not show any benefit of concurrent chemo radiation as compared to radiotherapy alone in locally advanced cervical cancer patients. This could be due to more bulk of tumor stage per stage, poor nutritional status, less number of patients in both arms, not enough to pick up statistically significant small difference in outcome.

Keywords
Carcinoma cervix, concurrent chemo radiation, cisplatin & 5-FU

 
© Copyright 2010 Journal of Cancer Research and Therapeutics.
Alternative site location: http://www.cancerjournal.net/

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