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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482
EISSN: 0973-1482
Vol. 6, No. 3, 2010, pp. 249-254
Bioline Code: cr10058
Full paper language: English
Document type: Review Article
Document available free of charge

Journal of Cancer Research and Therapeutics, Vol. 6, No. 3, 2010, pp. 249-254

 en Geftinib
Gupta, Ajay & Raina, Vinod

Abstract

Gefitinib is an orally active, highly selective, reversible inhibitor of the tyrosine kinase domain associated with the epidermal growth factor receptor (EGFR). EGFR gene mutations, never smoking status, Asian origin and adenocarcinoma histology are associated with good clinical responses to geftinib. Geftinib has generally been tried in the setting of chemotherapy refractory disease in patients who have failed at least one line of therapy. Trials are exploring use of geftinib as first line therapy in patients harboring EGFR mutations and also in the elderly. The most exciting feature of geftinib use is its potential for Lazarus responses in patients with poor performance status. Its use is associated with little toxicity. The success of geftinib suggests that it is important to understand the basic mechanisms underlying lung cancer in order to evolve better therapies. The review has been prepared after conducting extensive PubMed and Medline search for related articles.

Keywords
Geftinib, lung cancer, tyrosine kinase inhibitor

 
© Copyright 2010 Journal of Cancer Research and Therapeutics.
Alternative site location: http://www.cancerjournal.net/

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