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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482 EISSN: 0973-1482
Vol. 7, No. 2, 2011, pp. 214-216
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Bioline Code: cr11053
Full paper language: English
Document type: Case Report
Document available free of charge
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Journal of Cancer Research and Therapeutics, Vol. 7, No. 2, 2011, pp. 214-216
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High-grade plasmablastic neoplasm of humerus in an HIV-negative patient, which was indeterminate between plasmablastic lymphoma and plasmablastic myeloma
Mondal, Santosh Kumar.; Bera, Himel; Biswas, Pranab Kumar. & Mallick, Mamata Guha.
Abstract
Plasmablastic lymphoma (PBL) of bone is a rare neoplasm that shares many confusing cytomorphological and immunohistochemical features with plasmablastic plasma cell myeloma (PBPCM). A 47-year-old female patient presented with a bony swelling and bone pain in the left humerus for the last 6 months. On radiological examination (x-ray and computed tomography) it appeared to be a lytic lesion, and a pathological fracture was detected. The patient was HIV-negative. Fine needle aspiration (FNA) was done from the lesion, which was inconclusive. Subsequently, incisional biopsy was taken. Histopathological examination and immunohistochemistry confirmed a high-grade plasmablastic neoplasm, favoring a diagnosis of PBL. Most of the reported cases of PBL have occurred in HIV-positive patients, and the bone is a very rare site. PBL can be confused with PBPCM. A final diagnosis should be rendered only after thorough histopathological and immunohistochemical examination.
Keywords
HIV-negative, plasmablastic type, primary bone neoplasm
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© Copyright 2011 Journal of Cancer Research and Therapeutics. Alternative site location: http://www.cancerjournal.net/
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