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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482 EISSN: 0973-1482
Vol. 7, No. 3, 2011, pp. 286-291
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Bioline Code: cr11073
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Cancer Research and Therapeutics, Vol. 7, No. 3, 2011, pp. 286-291
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Study of the cytogenetic and non-cytogenetic factors in cervical carcinoma in the Jammu region of J and K state
Fotra, Roopali; Gupta, Shashi & Gupta, Subash
Abstract
Aim: The present study was aimed to analyze the chromosomal changes and also to work out the association of some of the non-cytogenetic factors in the confirmed cases of cervical carcinoma.
Materials and Methods: Slides for the chromosome study were prepared from the tumor growths of 78 patients as the diagnosed cases of cervical carcinoma. The slides so prepared were then subjected to G-banding to rule the involvement of different chromosomes in the progression of cervical cancer. Non-cytogenetic factors that are considered to be the risk factors for CaCx were also taken up during the present study to study the etiology of cervical cancer.
Results: Both the numerical and the structural chromosomal changes have been recorded in a majority of these growths. In most of the cases, numerical chromosomal changes (95%) outnumbered the structural aberrations.
Discussion: Aneuploidy was the most common numerical chromosomal aberration recorded in the majority of the tumor growths. Structural aberrations included translocations and deletions. Non-cytogenetic factors like multiparity, early marriage, poor genital hygiene and rural background were highly prevalent in the present study.
Keywords
Aberrations, aneuploidy, cervical carcinoma, parity
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© Copyright 2011 Journal of Cancer Research and Therapeutics. Alternative site location: http://www.cancerjournal.net/
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