Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
Vol. 7, No. 4, 2011, pp. 399-407
Bioline Code: cr11110
Full paper language: English
Document type: Review Article
Document available free of charge
Journal of Cancer Research and Therapeutics, Vol. 7, No. 4, 2011, pp. 399-407
© Copyright 2011 Journal of Cancer Research and Therapeutics.
Monoclonal antibodies in hematological malignancies: Past, present and future|
Tazi, I; Nafil, H & Mahmal, L
Much progress has been made during the last few decades in the treatment of hematological malignancies. Monoclonal antibodies (MoAbs) represent a major advance toward a targeted therapy that can dramatically improve the antitumor effect with a substantial reduction of toxicity derived from therapy. Unlike many small molecules, MoAbs offer unique target specificity. Several MoAbs are now in clinical use for hematologic malignancies therapy, and many others are currently undergoing clinical evaluation. This review summarizes the state-of-the-art MoAbs treatment, beginning with an overview of the scientific background to their synthesis, mechanism of action and choice of target antigen, mainly focusing on those antibodies that are currently in use in clinical practice. Despite these advances, significant challenges remain in the identification of optimal cellular targets, antibody forms and treatment schedules for therapeutic applications.
Hematological malignancies, monoclonal antibodies, review, therapy
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