Study - Topical lincomycin gel in acne vulgaris: A multicentric placebo controlled study

Introduction: Acne vulgaris is commonly treated with topical antibacterials. We evaluated lincomycin gel, a new topical formulation for mild to moderate acne. Material and Methods: A multicentric, randomized, double blind, placebo controlled, clinical trial was conducted with lincomycin hydrochloride in 2% gel form in 200 patients with grade II and grade III acne. The severity of acne lesions was noted at baseline and after 4 weeks. Results: About 70% cases in the study group showed a good to excellent response, which was significantly more as compared to 23% in the placebo group. The frequency and severity of adverse reactions in the two groups were similar. Conclusion: Lincomycin hydrochloride gel is an effective and safe treatment option for mild to moderate acne vulgaris.