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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0378-6323
Vol. 70, No. 4, 2004, pp. 234-235
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Bioline Code: dv04077
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Dermatology, Venereology and Leprology, Vol. 70, No. 4, 2004, pp. 234-235
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Case Report - Lichen planus secondary to hepatitis B vaccination
Agrawal Akhilesh, Shenoi ShrutakirtiD
Abstract
The association of lichen planus (LP) with liver diseases is now well established. Recent reports suggest that the hepatitis viruses may play a central role in this association. Lichen planus following hepatitis B vaccination is much more unusual. A 19-year-old previously healthy male developed itchy violaceous papules and plaques over the upper extremities eight to ten days after the first injection of hepatitis B vaccine. He developed similar lesions over the upper trunk, neck and lower leg after the second and third injections. A skin biopsy showed a lichenoid tissue reaction. Direct immunofluorescence (DIF) showed multiple colloid bodies and a strong continuous ragged basement membrane zone (BMZ) band with fibrinogen. HbsAg by ELISA and anti-HCV antibodies were negative. The patient was treated with oral steroids and the lesions improved. LP is a pruritic inflammatory dermatosis of unknown origin. An increased prevalence of liver disease in patient with LP has been reported. Since the first case reported by Rebora in 1990, about 15 cases of LP occurring after hepatitis B vaccination have been reported in the literature irrespective of the type of vaccine used.
Keywords
Lichen Planus, Hepatitis B vaccination
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© Copyright 2004 Indian Journal of Dermatology, Venereology, Leprology. Alternative site location: http://www.ijdvl.com
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