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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 70, No. 5, 2004, pp. 300-303
Bioline Code: dv04103
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 70, No. 5, 2004, pp. 300-303

 en Case Report - Darier's disease following radiotherapy for carcinoma of cervix
Chopra Supriya, Sharma Vinay, Nischal KC, Khopkar Uday, Baisane Chanda, Amare (Kadam) Pratibha


Darier-White disease is due to a defect in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2b). We report a case of carcinoma cervix in whom Darier′s disease manifested after the initiation of radiation therapy. Conventional cytogenetics on peripheral blood revealed non-clonal constitutional autosomal and X chromosome abnormalities suggesting radiation induced gene toxicity. Occurrence of Darier′s disease in our case could be due to treatment induced sustained differentiation in the Darier′s affected skin by an unknown mechanism. Late onset or sporadic Darier′s disease is the other possibility.

Darier′s disease, Carcinoma cervix, Chromosomal aberrations, Cutaneous manifestations

© Copyright 2004 Indian Journal of Dermatology, Venereology, Leprology.
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